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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Ilmu Dasar Jurnal Kedokteran Syiah Kuala e-Journal Pustaka Kesehatan Research Journal of Life Science Indonesian Journal of Biotechnology Journal of Agromedicine and Medical Sciences Mutiara Medika: Jurnal Kedokteran dan Kesehatan UNEJ e-Proceeding MNJ (Malang Neurology Journal) Health Notions Jurnal Pengabdian Pada Masyarakat Warta Pengabdian Multidiciplinary Journal Al-sihah: The Public Health Science Journal Manuju : Malahayati Nursing Journal Majalah Kedokteran Andalas Medical Technology and Public Health Journal Jurnal Inovasi Teknik Kimia Jurnal ABDINUS : Jurnal Pengabdian Nusantara AloHA International Journal of Health Advancement (AIJHA) STRADA Jurnal Ilmiah Kesehatan Jurnal Kesehatan dr. Soebandi
Erma Sulistyaningsih
Department Of Parasitology, Faculty Of Medicine, University Of Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Journal : Manuju : Malahayati Nursing Journal

 1 
Efek Antiaterogenik Ekstrak Pakis Sayur (Diplazium esculentum) melalui Penghambatan Vascular Cell Adhesion Molecule-1 pada Tikus Model Aterogenik Tristira Urvina; Erma Sulistyaningsih; Ika Rahmawati Sutejo
Malahayati Nursing Journal Vol 4, No 10 (2022): Volume 4 Nomor 10 2022
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v4i10.7722

Abstract

ABSTRACT Atherosclerosis is one cause of death. The thickening of the arterial walls which form atherosclerotic plaque can cause a blockage of the artery lumen and lead to thrombosis and blood flow. VCAM-1 activation causes increased adhesion of monocytes to endothelial walls and foam cell formation which is the key to the occurrence of atherosclerosis. Diplazium esculentum contains antioxidants and is able to inhibit the activation of VCAM-1. This study aimed to determine the effect of vegetable fern extract on the expression of VCAM-1 as an anti-atherogenic effect and the effective dose required. Experimental studies using randomized post test only control group design. Samples were grouped into 7 groups, namely K, KN, P1, P2, P3, P4, and P5. All group except K induced by atherogenic diet ang followed by the granting of vegetable fern extracts of 300 mg/kgBW in P1 groups, 600 mg/kgBW in P2 groups, 900 mg/kgBW in P3 groups, 1200 mg/kgBW in P4 groups, and 1500 mg/kgBW in P5 groups. The results showed a correlation between the dose of the extract given by the expression of VCAM-1, the greater the dose given VCAM-1 will be further hampered. The effective dose in rats was 2707, 19 mg/kg, this dose is equivalent to 4 kg of fresh vegetables fern in humans. Keywords: Atherosclerosis, Vegetable Fern Extract, VCAM-1  ABSTRAK Aterosklerosis merupakan salah satu penyebab kematian. Penebalan dinding arteri yang membentuk plak aterosklerosis dapat menyebabkan penyumbatan lumen arteri dan mengakibatkan trombosis dan gangguan aliran darah. Aktivasi VCAM-1 menyebabkan peningkatan perlekatan monosit pada dinding endotel dan pembentukan foam cell yang merupakan kunci terjadinya aterogenesis. Diplazium esculentum mengandung senyawa aktif yang bersifat antioksidan dan mampu menghambat aktivasi VCAM-1. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak pakis sayur terhadap ekspresi VCAM-1 sebagai efek antiaterogenik dan dosis efektif yang diperlukan. Studi eksperimental menggunakan randomized post test only control group design. Sampel dikelompokkan menjadi 7 kelompok, yaitu K, KN, P1, P2, P3,P4, dan P5. Tiap kelompok diinduksi diet aterogenik dilanjutkan dengan pemberian ekstrak pakis sayur sebesar 300 mg/kgBB, 600 mg/kgBB, 900 mg/kgBB, 1200 mg/kgBB, dan 1500 mg/kgBB. Hasil penelitian menunjukkan terdapat hubungan antara dosis ekstrak yang diberikan dengan ekspresi VCAM-1, semakin besar dosis yang diberikan ekspresi VCAM-1 akan semakin terhambat. Dosis efektif pada tikus adalah 2707, 19 mg/kgBB, dosis ini setara dengan 4 kg pakis sayur segar pada manusia. Kata Kunci: Aterosklerosis, Ekstrak Pakis Sayur, VCAM-1
Co-Authors Agustina Tri Endharti Al Munawir Aldi Cahya Muhammad Alfi Kamalia Aliyatul Farida Anas Bakhtiar Diyansah Ancah Caesarina Novi Marchianti Bagus Hermansyah Bagus Hermansyah Burhan, Niniek Cholis Abrori, Cholis Cicih Komariah Denaneer Rahmadatu Devita Prima Nurmasari Didi Candradikusuma Didi Candradikusuma Dini Agustina Dion Krismashogi Darmawan Dwi Wahyuni Dwita Aryadina Rachmawati Elly Nurus Sakinah, Elly Nurus Endang Sri Purwanti Wulandari Eqiel Navadz Akthar Alami Erfan Efendi Eva Sulawati Arum Fathul Hidayatul Hasanah Febrina Sylva Fridayanti, Febrina Sylva Fifil Sumarni Sumarni Firdha Novitasari Fitri Dika Maharani FX Ady Soesetijo, FX Ady Ghani Silahudin Hadi Prayitno Heni Fatmawati Hidayat Sujuti I Ketut Suada Ika Rahmawati Sutejo Intan Rachmawati Irawan Fajar Kusuma Iza Billa Fahmi Jarot Subandono Jarot Subandono Jauhar Firdaus Josef Sem Berth Tuda Kahfi Karunia Ilahi Laeli Kurniasari Laili, Elisa Fadia Laily Rahmawati Leersia Yusi Ratnawati Loeki Enggar Fitri Luh Putu Ratna Sundari Muhammad Hasan Ngurah Agung Reza Satria Nugraha Putra Nicole Berens-Riha Nicole Berens-Riha, Nicole Niniek Burhan Nur Aqmarina Kusumawardani Pralampita, Pulong Wijang Pungky Setya Arini Rina Fitriana Rina Fitriana Ristya Widi Endah Yani Rosita Dewi Salim Salim Samsul Arifin Samsul Arifin Sheilla Rachmania Silvi Ahmada Chasya Sinta Ariyani Sri Hernawati Sugiyanta Sugiyanta Sukarti Moeljopawiro Sukarti Moeljopawiro Thomas Loescher Thomas Loescher, Thomas Tristira Urvina Tuda, Josef Sem Berth Umar Zein Warda Ayu Nadira Wayan T. Artama Wayan T. Artama Widhi Dyah Sawitri Wiji Utami Winnie Almira Setyoadji Wiwien Sugih Utami Yunita Armiyanti